10 Ways Coffee Detrimentally Affects Both Mind and Body

Exposing the stark contrast between the profit-model medical/coffee industry-promoted benefits and actual real-life experience from coffee consumption

Topics in this article:

Alternatives to Coffee (Especially During the Withdrawal Phase)

Top 10 Reported Biological Benefits of Coffee

Top 10 Scientifically Documented Detriments to Coffee Consumption

Detriment #1: Reduced brain blood flow and long-term vascular effects

Detriment #2: Cognitive, memory, and mood disruption

Detriment #3: Dependence, tolerance, and "caffeine use disorder"

Detriment #4: Sleep disruption and circadian dysregulation

Detriment #5: Adrenal stress, cortisol, and hormonal disruption

Detriment #6: Anxiety, jitteriness, and psychiatric vulnerabilities

Detriment #7: Cardiovascular strain and blood pressure

Detriment #8: Bone, mineral, and reproductive risks

Detriment #9: Gastrointestinal, metabolic, and immune impacts

Detriment #10: Carcinogens, roasting byproducts, and accelerated aging

Summary

References

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Coffee has been used for centuries as a stimulating ritual beverage in Sufi religious practice, Middle Eastern and North African trade cultures, and eventually European cafés that became centers of intellectual life, before extending fully throughout the modern world of today.

As a former multi-decade consumer of coffee (easily 8 or more cups per day at one point), I am happy to report being off of coffee now for about 5 years.  While I miss the ritual of stopping by the organic coffee shops, as well as the taste of a quality organic brew (but not the side effects that go with it), I have some experience to draw from in making the following observations. 

I never had headaches or typical withdrawal side effects, having developed SumaRaj Tea for the very purpose of getting off of coffee back in 1999.  Problem is, from 1999 to around 2010 SumaRaj had yerba mate' in it, as a more nutritious and safe caffeine alternative. 

Then a friend told me that mate' affected the spleen more than other alternative caffeine sources.  I didn't believe that at first, until I began to look for the signs.  Sure enough, he was right.  I pulled mate' from the formula and have kept it caffeine-free since to capitalize on the restorative and gentle, liver cleansing benefits of the rest of the formula.

For a few years following I reintroduced coffee in diminishing amounts to my daily routine, until it simply became intolerable about 5 years ago, due to the side effects of just 1 or 2 cups of a quality organic brew. 

Today I still add one or more of the following caffeinated sources to SumaRaj, but have kept the blend caffeine-free out of respect for those that are sensitive to any form of caffeine at all.

Will I ever get off all caffeinated sources?  At the moment I do not see a reason to do so, as at 72, in many respects, but not all, I feel in a greater state of overall health today than I have ever been in my life.  This is for many reasons, beyond just diet and beverage choice.

I could certainly stand to exercise more, as I spend way too much time doing what I love most, which is writing articles like this one and sharing one-on-one with my beloved patrons of this work! 

Alternatives to Coffee (Especially During the Withdrawal Phase)

Obviously, I am not completely off caffeine today, as I consume green teas, matcha, pu-er (a multi-year ferment of green tea), unsweetened cacao powder, and guayusa, (which is the most balancing and restorative of the caffeinated varieties, although much milder in its stimulant effects), each of which possess a variety of health benefits when used appropriately (as with anything).

Guayusa provides both GABA and L-theanine, an amino acid that enhances GABA’s calming effects and promotes relaxed focus.  This synergy results in gentle, jitter-free energy, improved mental clarity, and reduced anxiety. 

So, I've found that Guayusa and other herbal teas (except yerba mate') make for effective transition beverages for those withdrawing from coffee in order to prevent the common headaches and withdrawal fatigue syndrome, although they lack the unique flavor of coffee that is loved so much. 

All of the above caffeinated teas, except for yerba mate' and cacao also contain L-theanine, supporting a more relaxed focus than coffee or mate'. 

Cacao's caffeine content is so low, it does not challenge the hormonal system in the way caffeinated beverages can, especially if consumed to extremes.

Adjustments in Taste Preference and Alertness

However, adjusting to the differences in taste preference and alertness means focusing on the pleasure of long-term vitality associated with higher degrees of overall health, in preference to the short-term feeling of energy and mental stimulation for a couple of hours, followed by the decline in both energy and mental acuity during the crash phase, which is then followed by a slow deterioration of overall health, energy levels, and mood over months and years.    

Supportively, historical and modern herbal monographs on coffee frequently note both beneficial digestive uses for coffee (as a bitter herb that stimulates bile, thus clearing toxins from the liver and emulsifying fats leaving the stomach), as well as its classic adverse effects—insomnia, palpitations, nervousness, and "coffeehouse" over-stimulation—long before modern neuroimaging quantified reduced brain blood flow and dependence syndromes. [3][6][1]

While coffee has some short-term documented metabolic and neurological benefits, it also exerts powerful drug-like effects on the brain, cardiovascular system, hormones, and sleep that can undermine long-term cognitive and physical health. 

Independent researchers and clinicians such as those at Johns Hopkins School of Medicine, Amen Clinics, and authors Marina Kushner, Stephen Cherniske, and Murray Carpenter describe a pattern in which modest usage producing short-term gains (alertness, mood, disease-risk correlations) can coexist with dependence, vascular constriction, and cumulative wear on mind and body. [1][2][3][4][5]

In addition to understanding the benefits and detriments of coffee, and in some cases of other caffeine sources (but not all, in my opinion), developing a new psychological approach toward addictions in general (applicable to any area of life), you may find: The Easy Way to Quit Caffeine: Live a healthier, happier life - (Allen Carr's Easyway) to be of interest along the way to finding balance in this and other areas of your life. 

Top 10 Reported Biological Benefits of Coffee

This article is about coffee, but most of the following research findings were made using standardized caffeine extracts, so as to eliminate variables in coffee types and effects of other components within the coffee bean. 

So, while it does not paint the complete picture of whole bean coffee's potential benefits and side effects, these studies can readily be applied to instances in which pure caffeine extracts are commonly added, like with colas, energy drinks, energy pills, weight loss medications, candies, and food additives of many kinds.

Below is a concise summary of commonly reported benefits from researchers that appear to be independent of studies performed by the coffee industry itself. 

Most of these benefits are dose-dependent, and most often prevalent at 1-3 cups/day.  In some cases the benefits are only while under the influence of caffeine, with immediate benefits diminishing over time with extended consumption:

1. Possible reduction in all-cause mortality and cardiovascular events in moderate consumers, often attributed to polyphenols and improved vascular and metabolic profiles, though lifestyle factors, dietary practices, and local environments could have been contributing causes of these life-extension benefits. [1][3]

2. Improved insulin sensitivity and lower risk of type 2 diabetes in observational cohorts, possibly mediated by chlorogenic acids (polyphenols with numerous health benefits, but which diminish with roasting) and bitter-induced bile secretion (though insulin sensitivity can be increased by simply moderating flesh foods, fat, and simple carbs, alkalizing the body, and eliminating its primary cause, being an underlying sugar-fat conflict at the cellular level. 

   Bile stimulation by the bitter coffee bean reduces this very conflict, but does not solve it, in the same way that dietary changes and supportive herbal formulas can.) [1]

3. Neuroprotective associations with lower incidence of Parkinson's disease and possibly some forms of dementia at moderate intakes, likely involving adenosine-receptor modulation (affecting energy levels) and antioxidant effects. [3][1]  Although, caffeine and theophylline are prototypical antagonists, blocking adenosine’s natural calming effects (improving sleep, for example) resulting in a stimulation of the nervous system. [16] 

   

4. Short-term enhancement of sustained attention, reaction time, and some types of memory encoding after acute caffeine doses, as shown in controlled tasks and Johns Hopkins memory studies.  Yet these benefits are temporary, not regenerative, and decline with long term use. [2][6]

5. Hepatic benefits, including lower risk of liver cirrhosis and some chronic liver diseases in frequent coffee drinkers, possibly via stimulation of detoxification enzymes and bile flow. [1]

6. Analgesic (headache relieving) adjuvant effect: caffeine can enhance the pain-relieving efficacy of some analgesics (e.g., in headache medicines), though this temporary effect overlaps with withdrawal-headache masking, resulting in long-term worsening of symptoms. [7][3]

7. Antioxidant intake: coffee is a major dietary source of phenolic compounds (chlorogenic acids), contributing to overall antioxidant capacity in many diets, although roasting reduces phenolic presence. [1][17] 

8. Temporary enhanced physical endurance and perceived exertion reduction in athletes at specific doses, by mobilizing fatty acids and stimulating the central nervous system. [8][1]

9. Possible reduced risk of certain cancers in some observational studies, although results are inconsistent and complicated by roasting-derived carcinogens like acrylamide. [1]

10. As a bitter herbal agent, coffee can stimulate bile production and fat emulsification in stomach chime (food passing into the duodemun and small intestines), which may indirectly support lipid clearance and blood sugar regulation when used judiciously, although there are herbal bitters that are superior to this function of coffee, and without the long-term side-effects listed below.  Digestive Bitters

These reported benefits coexist with substantial evidence of harm and dependence—especially at higher doses—described below.

Top 10 Scientifically Documented Detriments to Coffee Consumption

Detriment #1: Reduced brain blood flow and long-term vascular effects

Acute cerebral vasoconstriction

• Caffeine is an adenosine-receptor antagonist; in the brain, adenosine normally promotes vasodilation and blood flow, so blocking it constricts cerebral vessels and reduces cerebral blood flow (CBF). [3][1]   

• In the images, green, yellow, and brighter red sections indicate normal to high blood flow.  The top row indicates brain activity prior to consuming a 20 ounce coffee.  Below that are the caffeinated brain images that show significantly reduced blood flow to the key areas previously seen. [1]

  

• Human imaging studies show that a typical 200-250 mg caffeine dose (about 20 oz. or 2-3 cups of coffee) can reduce resting CBF by roughly 20-30%, with some reports suggesting even larger relative changes in particular regions. [4][1]

• Reduced blood flow to certain regions of the brain mean oxygen, nutrients, lipids, glucose, and detoxification fail to nourish and cleanse cells, neurons, and other essential activities including: [19] through [28]

  • Less oxygen delivery: Neurons depend on a constant oxygen supply to make energy (ATP); even a few minutes of low oxygen can injure or kill sensitive cells.

  • Less glucose and nutrients: The brain cannot store fuel, so restricted blood flow quickly limits glucose, vitamins, and other nutrients needed for signaling and repair.

  • Impaired maintenance and repair: Without enough energy and building blocks, neurons and support cells cannot maintain membranes, synapses, or myelin, so communication between brain regions deteriorates.

  • Increased waste and toxin buildup: Reduced circulation slows removal of metabolic byproducts and inflammatory molecules, which can damage cell structures and worsen oxidative stress.

  • Localized symptoms: When a particular area is underperfused (reduced blood flow), its jobs (e.g., memory, attention, movement, mood) may weaken, leading to problems like brain fog, slower thinking, or poor coordination.

  • Long-term risk: Chronic low blood flow can contribute to neurodegeneration and vascular cognitive impairment, while severe or sudden loss of flow can cause stroke-like injury.

When writing Is Coffee Really Good For Your Health? several years ago, I came across a video of an investigative reporter, Lisa Stark, who asked her physician to do an MRI before and after drinking a single 20-oz coffee.

The scans revealed a reduced overall blood flow to her brain by about 53%, as determined by her physician. This merely illustrates how dramatically some individuals may respond to coffee's influence on the brain. 

It is of no surprise that this article has since been scrubbed from the net.  However, here is the WayBack Machine's storage of the video documentary, yet no longer able to be played: Caffeine's Effects on the Human Brain—Lisa Stark looks at how caffeine interacts with our brain.

Sustained daily use adaptation and withdrawal

• With daily use, the brain compensates for frequent constriction by up-regulating adenosine receptors and altering vascular tone; when caffeine is withdrawn, rebound vasodilation and increased blood flow occur, often manifesting as classic withdrawal headaches. [9][3]

• Johns Hopkins-linked work on caffeine withdrawal documents significantly increased cerebral blood flow velocity, increased EEG theta power, and symptoms of headache, drowsiness, and reduced concentration after just 18-24 hours off of caffeine in regular users. [9][7][3]

Long-term structural and functional concerns

• Dr. Daniel Amen, a strong advocate of green tea, but not of coffee, has repeatedly warned that caffeine constricts blood flow to the brain and can contribute to premature brain aging; he advises patients to avoid caffeine before SPECT scans because it artificially lowers regional perfusion (oxygenated blood flow) to various areas of the brain. [10][11][4]

• Although some of the dramatic SPECT images often combine smoking and caffeine, the convergence of MRI/CBF studies and Amen's perfusion-oriented practice places an emphasis on reduced blood flow to the brain as the #1 detriment of chronic coffee use. [4][1]

Detriment #2: Cognitive, memory, and mood disruption

Artificial alertness and baseline impairment

• Caffeine intake improves vigilance and reaction time, but heavy daily users often show little to no net advantage over non-users, indicating a lessening of benefits with prolonged use; performance gains from coffee consumption partly reflect the temporary reversing of prior caffeine-induced fatigue, which gets worse over time, in that coffee does not have the glandular regenerative benefits of other nutritive herbs. [5][3]  Adrenal Revive, Revitalize for Men / Women, Adaptogen & Mushroom Blend

• Amen Clinics notes that caffeine-induced jitteriness and hyper-arousal can actually impair sustained mental clarity and fine task performance, despite subjectively feeling more "wired." [4]

Memory and connectivity changes

• Johns Hopkins research found that a single caffeine dose can enhance long-term memory consolidation, but this does not necessarily translate into better everyday cognition in heavy users, especially when sleep is compromised. [6][2] 
  Memory, Mental Clarity & Eyesight

  

• A study cited by Amen Clinics reports that sustained daily high caffeine intake is associated with altered functional connectivity in networks governing attention, motor control, and learning, suggesting that regular heavy use may subtly rewire brain networks in ways not uniformly beneficial. [4]

Mood swings, anxiety, and depression

• Marina Kushner's "The Truth About Caffeine" and Stephen Cherniske's "Caffeine Blues" both describe a pattern of anxiety, irritability, and "crash" depression emerging as caffeine presence in the blood and catecholamine levels (involved in flight-or-flight response) fall after the initial high. [12][13]

• Clinically, caffeine use disorder includes restlessness, nervousness, insomnia, and depressed mood on withdrawal, underscoring the drug-like impact of coffee on mood regulation. [5]

Detriment #3: Dependence, tolerance, and "caffeine use disorder"

Behavioral and neurobiological dependence

• The Behavioral Biology Research Center at Johns Hopkins has produced foundational work showing that caffeine produces a characteristic withdrawal syndrome (headache, fatigue, decreased alertness) at doses as low as 100 mg/day (1-2 cups) in susceptible individuals. [9][3]

• Tolerance develops quickly to many of caffeine's subjective and cardiovascular effects, prompting escalating intake to achieve the same perceived level of alertness. [5][3]

Diagnostic criteria and difficulty quitting

• Johns Hopkins and other researchers have proposed "caffeine use disorder" based on inability to cut down, continued use despite harm, and significant withdrawal, paralleling patterns seen with other psychoactive substances. [5]

• Kushner and Cherniske emphasize how marketing normalizes dependence, framing withdrawal symptom relief from another dose as a "benefit," and highlight that many users underestimate the difficulty of quitting until they attempt sustained abstinence, giving the body time to gradually recover from coffee's degenerative effects. [13][12]

Detriment #4: Sleep disruption and circadian dysregulation

Insomnia and reduced sleep quality

• Caffeine has a half-life of about 4-6 hours (thus complete depletion of caffeine in the system could extend up to 12 hours), so afternoon or evening coffee can impair sleep onset and reduce total sleep time. [8][1]

• Even a single cup or two of coffee in the morning can reduce slow-wave (deep) sleep and REM density in sensitive individuals at night, leading to non-restorative sleep and cumulative sleep debt. [8] 

• Sensitivity in individuals are an indication of adrenal and spleen depletion, partially caused by caffeinated overstimulation.  Adrenal Revive, Spleen Builder

Adenosine hijacking

• Adenosine is a key sleep-inducing signal; caffeine blocks adenosine receptors, temporarily masking sleepiness without resolving underlying fatigue. [8][1]

• Murray Carpenter's "Caffeinated" describes how day-long caffeine use can keep the brain in a chronic "sleep-debt state," requiring more caffeine the next day to counter the prior night's impaired rest. [14][8]

Detriment #5: Adrenal stress, cortisol, and hormonal disruption

Elevated cortisol and stress physiology

• Coffee acutely increases cortisol and catecholamines (adrenaline, noradrenaline), mimicking a fight-or-flight response even in the absence of physical threat or exertion. [1]

• Repeated surges from another cup of coffee contribute to chronic (sustained) sympathetic dominance, which can worsen anxiety, insulin resistance, and visceral fat accumulation. [4][1]

Long-term adrenal and endocrine effects

• My extensive personal experience as a former coffee drinker confirms that my assessment, from a body system point of view, being adrenal exhaustion, kidney strain, and spleen stress with long-term heavy coffee use, correspond with clinical reports of fatigue, shakiness, and hormone imbalances, characteristic of:

  • under-performing adrenal hormone production and low blood sugar or sustained fight-or-flight shakiness 

  • deficient splenic function resulting in anxiety, irritability, depression, loss of motivation and drive, spaciness, and deficient energetic (electrical) support for adrenal hormone production

    

  • brain function disorders from chemical, heavy metal, or mold toxicity in coffee beans triggering hyperactive behavior, rigidity of opinion, obsessive compulsive behavior, and attention deficit resulting in a reduced ability to stay focused on written materials or conversations, outside of brief soundbites

  • dehydration and overacidity resulting in diminished blood filtering powers of the kidneys resulting in toxicity backlog, frequent urination, and a tendency toward high blood pressure

  • If sugar is added to the beverage or in the diet, these symptoms are significantly amplified

• Cherniske likewise argues that chronic caffeine pushes the stress-hormone system into overdrive, accelerating the aging process and undermining foundational vitality ("jing") in Traditional Chinese Medicine energetic language. [13]

Detriment #6: Anxiety, jitteriness, and psychiatric vulnerabilities

Anxiety and panic attacks

• Caffeine can provoke or worsen generalized anxiety, panic attacks, and agitation, especially in those with anxiety disorders or high trait sensitivity. [5][4]

• Many psychiatric clinics—including Amen Clinics—routinely assess caffeine intake because it can amplify symptoms of bipolar disorder, PTSD hyper-arousal, and OCD by increasing arousal and intrusive thoughts. [4]

Irritability and emotional volitility

• Overstimulated prefrontal circuits and impaired impulse control under catecholamine (fight-or-flight) overload can lead to heightened emotions, irritability, and proneness to anger.

• Kushner and Carpenter both detail how daily cycles of over-stimulation, followed by the typical crash, can destabilize mood and worsen underlying depressive tendencies, once the stimulant effect wears off. [12][8]

Detriment #7: Cardiovascular strain and blood pressure

Immediate and chronic blood-pressure effects

• Caffeine typically raises blood pressure and heart rate acutely.  Even in habitual users, modest but significant systolic and diastolic increases are common. [4][1]

• A large genetic study suggests that caffeine can induce or aggravate hypertension, a well-recognized risk factor for cardiovascular disease and stroke. [1]

Vascular integrity and homocysteine

• Amen Clinics cites research showing that 200 mg of caffeine (1-2 cups of coffee) can raise homocysteine, an inflammation and vascular damage marker associated with higher risks of thrombosis and cardiovascular events. [4]

• The combination of elevated blood pressure, vasoconstriction, and pro-inflammatory markers may contribute to microvascular damage, including within brain capillaries, over long durations. [1][4]

Detriment #8: Bone, mineral, and reproductive risks

Bone density and fracture risk

• An umbrella review found associations between high coffee intake and increased fracture risk in women, via calcium loss and altered bone metabolism.  As an acidic beverage (typically around 5.5 pH), daily use without supplementing alkalizing dietary offsets (like seweeds, algae, and dark green vegetables) results in the siphoning of alkalizing calcium from bones to keep the blood pH within the critical narrow parameters of 7.35-7.45.

• Caffeine modestly increases urinary calcium excretion and may, over time, contribute to decreased bone mineral density, especially when the diet and vitamin D are suboptimal. [1]

Iron absorption

• Coffee and the tannins/polyphenols in black/green tea, cacao, and red wine counter iron absorption. [18]

• Phytates/phytic acid found in whole grains, bran, legumes, nuts, and seeds, as well as high calcium foods (like milk, cheese, and yogurt) inhibit non-heme (vegetable-sourced) iron absorption when consumed with or soon after meals, which can worsen or unmask iron-deficiency anemia. [18]

• Herbal and nutritional monographs routinely caution anemic or pregnant individuals about combining coffee with iron-rich meals or supplements because of this effect. [18]

• Vitamin C in fruits and berries, as well as organic acids (citric, malic, and tartaric acids) from many fruits and fermented foods increase non-heme iron absorption from plants. [18]

• Fruit-based vitamin C also counteracts iron absorption inhibitors such as phytates in grains and legumes, polyphenols in tea, coffee, and red wine, and calcium in dairy products. [18]

• Heme iron (from flesh foods) is absorbed automatically, which can be useful in deficiency, but may contribute to excess iron if intake is chronically high, especially in people predisposed to iron overload. 

• Non-heme iron (from plants) is more tightly regulated by the body, so uptake tends to increase when stores are low and decrease when stores are high.  

• Normal stomach acid also improves solubility and absorption of non-heme iron. [18]

Pregnancy outcomes

• Independent observational data link higher coffee intake in pregnancy with increased risks of low birth weight, preterm birth, and pregnancy loss, with no clear safe threshold above very low or zero intake. [1]

• Because caffeine crosses the placenta and fetal metabolism is slow, many guidelines advise minimizing or avoiding coffee entirely during pregnancy despite industry-supported attempts to normalize moderate use. [1]

Detriment #9: Gastrointestinal, metabolic, and immune impacts

Acidity, reflux, and GI irritation

• Coffee is acidic and can relax the lower esophageal sphincter, aggravating heartburn and acid-reflux in susceptible people; it may also irritate gastric mucosa, leading to nausea or stomach upset.[1]

• Coffee-stimulated over-acidity, frequent urination, and kidney strain, coupled with added sugar, cream, and pastries, compound gastrointestinal and metabolic stress (a deficiency or excess of nutrients or toxins affecting organs and chemistry).

Blood sugar and lipid (fat) interplay

• While some epidemiology suggests lower diabetes risk, evidence reveals that, while under the immediate influence of caffeine, insulin sensitivity is actually reduced and post-prandial glucose is raised, particularly in individuals with existing insulin resistance. [1]

  

• Coffee's beneficial "bitter" action on bile and fat emulsification prior to entering the bloodstream can be more safely replicated by non-caffeinated bitters (e.g., dandelion, gentian, turmeric), gaining digestive benefits without the stimulant burden.  Digestive Bitters

Immune modulation and viral overgrowth

• Psychoneuroimmunology studies confirm that chronic stress-hormone elevation and sleep loss are well-documented contributors to impaired innate immune response powers. [8][1]

• Chronic cortisol elevation coupled with the sugar and fat additives, along with typical over-acidity, can lead to coffee-driven stress and opportunistic overgrowth of a variety of pathogens (whose purpose is to clean up the excesses and toxins), contributing to fatigue, joint pain, and "Lyme-like" symptoms.  Immune Power

Detriment #10: Carcinogens, roasting byproducts, and accelerated aging

Roasting-derived toxins

• Coffee contains roasting by-products such as acrylamide and 4-methylimidazole, both of which have carcinogenic potential in animal models; levels peak at certain roast degrees and then partially decline but do not disappear.

• Regulatory bodies in some regions have scrutinized acrylamide levels in coffee and related products, especially when consumed in large quantities over decades. [1]

Dehydration and skin aging

• Caffeine has a mild diuretic effect, especially in non-tolerant users.  When fluid intake does not compensate, this can contribute to systemic dehydration. [4][1]

• Sustained daily coffee use is also associated with accelerated aging/wrinkles.  The Western concepts of collagen loss, oxidative stress, and dehydration is characterized in the traditional Chinese concept of "kidney jing depletion", resulting in accelerated aging.

Brain aging and structural changes

• A large cohort analysis referenced by Amen Clinics found that very high coffee consumption (more than six cups per day) was associated with reduced total brain volume and higher risks of dementia and stroke, although causality remains under investigation. [4]

• Combined with long-term oxygenated blood flow reduction, sleep disruption, and vascular stress, heavy coffee use plausibly accelerates certain aspects of neurovascular aging, even in the presence of some short-term neuroprotective associations at lower intakes. [4][1]

Summary

Coffee is a potent psychoactive drug embedded in modern cultural rituals and supported by numerous studies showing short-term health benefits at modest doses, mostly while still under the influence of the caffeine.

At the same time, independent researchers, herbal clinicians, and critical authors like Kushner, Cherniske, Carpenter, Amen, as well as my personal experience, all converge on several major concerns: marked reductions in brain blood flow, dependence and withdrawal cycles, sleep and hormonal disruption, cardiovascular and skeletal strain, and subtle but significant erosions in cognitive stability and long-term vitality. [2][10][12][13][9][3][4][1]

For individuals who prefer a well oxygenated, nourished brain, stable moods, restorative sleep, and long-term resilience, the evidence favors minimizing or eliminating daily coffee while obtaining digestive and antioxidant benefits from non-caffeinated bitters and nutritive herbs instead. [8][1]

Digestive Bitters, -Immune Power, -Adrenal Revive, -Spleen Builder, -Revitalize for Men /Women, -Adaptogen & Mushroom Blend, -Memory, Mental Clarity & Eyesight

 

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References

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC2748160/

[2] https://hub.jhu.edu/2014/01/12/caffeine-enhances-memory/

[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC2738587/

[4] https://www.amenclinics.com/blog/what-does-coffee-really-do-to-your-brain/

[5] https://hub.jhu.edu/2014/02/07/caffeine-really-is-a-drug/

[6] https://www.nbcnews.com/health/health-news/brain-scans-coffee-drinkers-caffeine-rcna91680

[7] https://www.sciencedaily.com/releases/2009/05/090501162805.htm

[8] https://migrainecollaborative.org/new-insight-into-caffeines-effects-on-wakefulness-sleep-and-brain-blood-flow

[9] https://pubmed.ncbi.nlm.nih.gov/10672630/

[10] https://www.youtube.com/watch?v=rg-QSrCbeqo

[11] https://www.facebook.com/drdanielamen/photos/a.378208757412/10151504111387413/?id=175557637412

[12] https://forum.tuxdigital.com/default.aspx/textbooks/KDfR9X/Chemistry_Project_To_Determine_The_Caffeine_In_Tea_Samples.pdf

[13] https://www.lindsey.edu/academics/majors-and-programs/English/img/AKO-Review23.pdf

[14] https://www.amazon.com/Truth-About-Coffee-Marina-Kushner/dp/1632270757

[15] https://www.facebook.com/SteveBartlettShow/videos/this-doctor-says-caffeine-is-worse-than-you-realise-️/9450128261712020/

[16] https://synapse.patsnap.com/article/what-are-adenosine-receptor-modulators-and-how-do-they-work

[17] https://pmc.ncbi.nlm.nih.gov/articles/PMC9281936/

[18] https://www.ncbi.nlm.nih.gov/books/NBK540969

[19] https://www.headway.org.uk/about-brain-injury/individuals/types-of-brain-injury/hypoxic-and-anoxic-brain-injury/

[20] https://birthinjurycenter.org/oxygen-deprivation/

[21] https://my.clevelandclinic.org/health/diseases/6025-cerebral-hypoxia

[22] https://medlineplus.gov/ency/article/001435.htm

[23] https://www.ncbi.nlm.nih.gov/books/NBK537310/

[24] https://www.vinmec.com/eng/blog/how-does-the-body-react-when-there-is-a-lack-of-oxygen-to-the-brain-en

[25] https://en.wikipedia.org/wiki/Cerebral_hypoxia

[26] https://brooksrehab.org/conditions/brain-injury/how-long-can-the-brain-go-without-oxygen/

[27] https://www.spinalcord.com/blog/what-happens-to-the-brain-after-a-lack-of-oxygen

[28] https://www.brainfacts.org/diseases-and-disorders/neurological-disorders-az/diseases-a-to-z-from-ninds/cerebral-hypoxia